Performance model of interactive video-on-demand systems

An interactive video-on-demand (VoD) system allows users to access video services, such as movies, electronic encyclopedia, interactive games, and educational videos from video servers on a broadband network. This paper develops a performance evaluation tool for the system design. In particular, a user activity model is developed to describe the usage of system resources, i.e., network bandwidth and video server usage, by a user as it interacts with the service. In addition, we allow batching of user requests, and the effect of such batching is captured in a batching model. Our proposed queueing model integrates both the user activity and the batching model. This model can be used to determine the requirements of network bandwidth and video server and, hence, the trade-off in communication and storage costs for different system resource configurations.published_or_final_versio

An efficient handoff management scheme for mobile wireless ATM networks

A new handoff management scheme for wireless ATM networks is proposed. In this scheme, all cells are connected to their neighboring cells by permanent virtual circuits (PVCs) and to the access switch (AS) by switched virtual circuits (SVCs) which are only for new calls. Some carefully chosen cells, called rerouting cells, are also connected to the AS by PVCs. In summary, if a mobile roams to an ordinary neighboring cell, its traffic path is simply elongated by a PVC connecting the old and new cells. If a mobile roams to a rerouting cell, its traffic path is rerouted to a PVC between the AS and rerouting cell. By using PVC's for handoff calls, we can guarantee fast and seamless handoff. At the same time, our scheme improves the path efficiency by limiting the maximum number of hops that a path can be extended. Also, allowing path rerouting at a suitable time means the network resources are more efficiently utilized.published_or_final_versio

The potential of antisense oligonucleotide therapies for inherited childhood lung diseases.

Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design. Through targeting the pre-mRNA, antisense oligonucleotides can alter splicing and induce a specific spliceoform or disrupt the reading frame, target an RNA transcript for degradation through RNaseH activation, block ribosome initiation of protein translation or disrupt miRNA function. The recent accelerated approval of eteplirsen (renamed Exondys 51™) by the Food and Drug Administration, for the treatment of Duchenne muscular dystrophy, and nusinersen, for the treatment of spinal muscular atrophy, herald a new and exciting era in splice-switching antisense oligonucleotide applications to treat inherited diseases. This review considers the potential of antisense oligonucleotides to treat inherited lung diseases of childhood with a focus on cystic fibrosis and disorders of surfactant protein metabolism

The architecture of built pedagogy for active learning-a case study of a university campus in Hong Kong

202002 bcrcVersion of RecordPublishe

Modeling study of design flow rates for cascade water supply systems in residential skyscrapers

202012 bcrcVersion of RecordPublishe

Environmental evaluation of pump replacement period in water supply systems of buildings

202311 bckwAccepted ManuscriptRGCPublishedGreen (AAM

Enhanced blocking probability evaluation method for circuit-switched trunk reservation networks

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Blocking Probability Estimation for Trunk Reservation Networks

IEEE International Conference on Communications (ICC)22